Journal of Pathology and Translational Medicine

Case Study

Colonic Adenocarcinoma Arising from Gastric Heterotopia: A Case Study: Hyoungsuk Ko, Shin Young Park, Eun Jung Cha, Jang Sihn Sohn; Korean J Pathol. 2013;47(3):289-292. Published online June 25, 2013; DOI: https://doi.org/10.4132/KoreanJPathol.2013.47.3.289

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Heterotopic gastric mucosa occurs in all areas of the gastrointestinal tract including the nasopharynx, tongue, esophagus, small intestine, colon, and rectum. Gastric heterotopia of the large bowel is infrequent, and most cases have been reported in the rectum. Review of the literature has revealed only eight cases involving the colon proximal to the rectum. Little is known of the natural history of gastric heterotopias, except that. It usually presents with gastrointestinal bleeding, though other serious complications such as bowel perforation, intussusceptions, and fistula formation, are possible. Further, it is unclear whether heterotopic gastric mucosa progresses to malignancy. Herein, we describe a case of adenocarcinoma of the transverse colon arising from gastric heterotopia. To the best of our knowledge, this is the first report of adenocarcinoma arising from heterotopic gastric mucosa in the colon.

Citations

Citations to this article as recorded by

Intussusception of Heterotopic Gastric Mucosa in the Transverse Colon: A Rare Cause of Perforation and Bleeding
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Cureus.2024;[Epub] CrossRef
Gastric heterotopia of colon found cancer workup in liver abscess: A case report
Jun Gi Park, Jeong Ill Suh, Yeo Un Kim
World Journal of Clinical Cases.2022; 10(15): 5012. CrossRef
Gastric heterotopia in the ileum mimicking Meckel's diverticulum
Reza Shojaeian, Negar Nekooei, Paria Dehghanian
Journal of Pediatric Surgery Case Reports.2022; 84: 102361. CrossRef
Sometimes Things Are Not Where They Are Supposed to Be: A Case Report of Gastric Heterotopia in the Rectum
Asher Lippe, Scott Lippe
Physician's Journal of Medicine.2022;[Epub] CrossRef
Gastric heterotopia of the rectum
Eduardo Dantas, Diva Yamaguti, Kendi Yamazaki
Gastroenterología y Hepatología.2021; 44(8): 579. CrossRef
Bleeding Gastric Heterotopia of Cecal Diverticulum in an Adolescent: A Case Report
Hyun-Il Seo, Jae-Young Kwak
Advances in Pediatric Surgery.2021; 27(1): 32. CrossRef
Gastric heterotopia of the rectum
Eduardo Dantas, Diva Yamaguti, Kendi Yamazaki
Gastroenterología y Hepatología (English Edition).2021; 44(8): 579. CrossRef
Polypoid Gastric Heterotopia of Colon
Marcela Adriana Duran Alvarez, Carla Noemi Tafur Sanchez
GE - Portuguese Journal of Gastroenterology.2020; 27(1): 65. CrossRef
Heterotopic Respiratory Mucosa in the Rectum: An Unusual Type and Site of Heterotopia in the Gastrointestinal Tract
Caroline Bsirini, Pratyusha Tirumanisetty, Joseph N. Dytoc, Diana Agostini-Vulaj, Christopher Steevens, Asad Ullah, Aaron R. Huber
International Journal of Surgical Pathology.2019; 27(2): 221. CrossRef
Perforation of Heterotopic Gastric Mucosa in ileal duplication in an adult: A case report
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Journal of Surgical Case Reports.2019;[Epub] CrossRef
Mixed adenoneuroendocrine carcinoma of the tongue arising within a congenital enteric cyst
Louis J. Ligthelm, Belinda K. Bunn, Erich J. Raubenheimer, Willie F. P. van Heerden
Head & Neck.2018;[Epub] CrossRef
The outlet patch: gastric heterotopia of the colorectum and anus
Abul A S R Mannan, Michael Vieth, Armen Khararjian, Binny Khandakar, Dora Lam‐Himlin, David Heydt, Feriyl Bhaijee, Henry J Venbrux, Kathleen Byrnes, Lysandra Voltaggio, Norman Barker, Songyang Yuan, Elizabeth A Montgomery
Histopathology.2018; 73(2): 220. CrossRef
Large heterotopic gastric mucosa and a concomitant diverticulum in the rectum: Clinical experience and endoscopic management
Wen-Guo Chen, Hua-Tuo Zhu, Ming Yang, Guo-Qiang Xu, Li-Hua Chen, Hong-Tan Chen
World Journal of Gastroenterology.2018; 24(30): 3462. CrossRef
Gastric heterotopia in the rectum. A rare cause of ectopic gastric tissue
George A. Salem, Javid Fazili, Tauseef Ali
Arab Journal of Gastroenterology.2017; 18(1): 42. CrossRef
Gastric heterotopia in rectum: A literature review and its diagnostic pitfall
Peyman Dinarvand, Ashley A. Vareedayah, Nancy J Phillips, Christine Hachem, Jinping Lai
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Heterotopic gastric mucosa in the anus and rectum: first case report of endoscopic submucosal dissection and systematic review
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Original Articles

Clinicopathologic Study of Chromosomal Aberrations in Gastric Lymphomas of Korean Patients.: Wook Youn Kim, Jung Ho Kim, Hyoungsuk Ko, Young A Kim, Yoon Kyung Jeon, Chul Woo Kim; Korean J Pathol. 2009;43(1):5-12.; DOI: https://doi.org/10.4132/KoreanJPathol.2009.43.1.5

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Abstract PDF

BACKGROUND
The incidence and clinical correlation of MALT1 translocation and numerical aberrations in Korean gastric MALT lymphoma patients have been rarely reported. We studied the incidence and clinicopathologic relationship of these chromosomal aberrations in Korean gastric lymphomas.
METHODS
Seventy-six gastric lymphomas, which consisted of 40 low grade MALT lymphoma, 4 high grade MALT lymphoma and 32 diffuse large B-cell lymphoma (DLBCL) cases, were analyzed for the detection of t(11;18) API2-MALT1, t(14;18) IgH-MALT1 and aneuploidies of chromosomes 3 or 18 using fluorescence in situ hybridization.
RESULTS
The t(11;18) was demonstrated in 3 low grade MALT lymphomas (7.5%) and one DLBCL, which was associated with advanced stage, deeper invasion, and disease progression or relapse. The t(14;18) was demonstrated in none of these cases. Trisomy 3 and 18 were detected in 8 (11%) and 11 of 76 cases (12.5%) respectively, and found only in translocation-negative cases. Two of 4 high grade MALT lymphomas showed trisomy 18. All patients survived with successful second treatment after progression or relapse.
CONCLUSIONS
The t(11;18) API2-MALT1 was not quite frequent in Korean low grade gastric MALT lymphomas and was associated with advanced clinical situations. Overall prognosis was good for long-term follow-up regardless of progression or relapse.

Citations

Citations to this article as recorded by

Clinicopathologic Study of Chromosomal Aberrations in Ocular Adnexal Lymphomas of Korean Patients
Hokyung Choung, Young A Kim, Namju Kim, Min Joung Lee, Sang In Khwarg
Korean Journal of Ophthalmology.2015; 29(5): 285. CrossRef

Histological and Immunohistochemical Evaluation of Ductal Carcinoma In Situ Co-Existing with Triple-Negative Carcinoma of the Breast.: Hyesil Seol, Hyoungsuk Ko, In Ae Park; Korean J Pathol. 2008;42(6):373-380.

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Abstract PDF: BACKGROUND
Triple-negative breast carcinomas (TNBCs) are associated with high-grade histological tumor and a poor clinical outcome. In this study, we evaluated the histology and immunohistochemical features of DCIS co-existing with TNBC to determine the characteristics of the precursor lesions of TNBC. METHODS: Among the 1,610 cases of breast carcinoma, we selected the TNBCs with DCIS (n=196), and compared the pathological and immunohistochemical findings of the DCIS with those of the invasive carcinoma areas.
RESULTS
Among the 1,610 breast carcinomas, the TNBCs accounted for 330 cases (20.5%) and there were 196 cases with DCIS. The TN-DCIS cases exhibited high nuclear (94.5%) and histological (94.5%) grades, comedo-necrosis (68.9%) and a small extent of the DCIS-involved area. Immunohistochemically, a p53 expression was present in 48.4% of the TN-DCIS cases and a high Ki-67 index was present in 31.5%. The same TN immunohistochemical profiles as the carcinoma were detected in 109 of the 124 (87.9%) cases, but different profiles were observed in 15 of the 124 (12.1%) cases. The 15 discordant cases were associated with a low histological grade (p=0.037), low p53-positivity (p=0.006) and a low Ki-67 index (p=0.026), as compared to the invasive carcinomas. CONCLUSIONS: The results of this study suggest that TN DCIS is a highly probable, but not obligate, precursor lesion of TNBC.

Case Report

Epstein-Barr virus-associated Inflammatory Pseudotumor-like Follicular Dendritic Cell Tumor in the Spleen of a Patient with Diffuse Large B Cell Lymphoma: A Case Report and Review of the Literature.: Sun Och Yoon, Hyoungsuk Ko, Baek hui Kim, Ghee Young Kwon, Yoon Kyung Jeon, Chul Woo Kim; Korean J Pathol. 2007;41(3):198-202.

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Abstract PDF: We report a case of an Epstein-Barr virus (EBV)-associated inflammatory pseudotumor-like follicular dendritic cell tumor (IPT-like FDC tumor). The tumor occurred in the spleen of a 64-year-old woman with a history of a diffuse large B-cell lymphoma (DLBCL) of neck nodes that presented four years ago. The splenectomy specimen revealed a 5 cm-sized, tan-colored and well-circumscribed mass. Histologically, spindle or ovoid cells with large vesicular nuclei were admixed with abundant inflammatory cells. Immunohistochemically, spindle cells were positive for FDC marker CD35, but negative for CD20, CD30 and ALK. EBV was detected almost exclusively in spindle cells by EBER in situ hybridization. IPT-like FDC tumors are rare, and are recognized as a distinctive clinicopathologic variant of FDC tumors. Among only 18 similar cases reported in the English language literature, the present case is the first case of a patient with a history of DLBCL.

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